Unclassified · Medical Literature

[Correspondence] High-temperature tolerance of bat and pangolin sarbecoviruses versus SARS-CoV-2

Authors
Luo Chen, Ziyi Guo, Yukun Zhu, Keiya Uriu, Kei Sato
Journal
The Lancet Microbe
Publication date
2026-03-20
Source
rss_lancet_mic
Original record ID
210179
Summary status
error
Analysis status
error
Original last updated
2026-08-10T06:57:14.000Z

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Abstract

Understanding the mechanisms underlying host adaptation in emerging viruses is essential for future pandemic preparedness. Data published in 2021 suggest that thermosensitivity influences the viral fitness of SARS-CoV-2 in humans,1 with later omicron subvariants (eg, BQ.1.1) showing lower replication at elevated temperatures than earlier strains (eg, Delta and BA.5).2 The later-emerging strain of the omicron XBB variant, EG.5.1, showed enhanced spike–angiotensin-converting enzyme 2 interactions at lower temperatures than earlier omicron XBB subvariants (eg, XBB.1).