Unclassified ยท Medical Literature

[Correspondence] Semaglutide treatment fails but might prevent Alzheimer's disease

Authors
Ivan Koychev, Rury R Holman
Journal
The Lancet
Publication date
2026-08-15
Source
rss_lancet
Original record ID
270223
Summary status
error
Analysis status
error
Original last updated
2026-08-17T07:43:23.000Z

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Abstract

We read with interest Lon S Schneider's Comment1 on the evoke and evoke+ trials2 of oral semaglutide in early symptomatic Alzheimer's disease. While we agree that these studies do not support semaglutide as a treatment for established Alzheimer's disease, we caution against interpreting the findings as evidence against the broader preventive potential of GLP-1 receptor agonists.