Unclassified · Medical Literature

[Articles] Dual β-lactam therapy against high-risk Pseudomonas aeruginosa isolates: a dynamic in-vitro infection model study integrating population genomics with quantitative systems pharmacology modelling and simulations

Authors
Siobhonne K J Breen, Sara Cortés-Lara, Jessica R Tait, Kate E Rogers, Wee Leng Lee, Megan Faith, Alice E Terrill, Dominika T Fuhs, Marina Harper, Carla López-Causapé, Roger L Nation, John D Boyce, Antonio Oliver, Cornelia B Landersdorfer
Journal
The Lancet Microbe
Publication date
2026-06-25
Source
rss_lancet_mic
Original record ID
270274
Summary status
error
Analysis status
error
Original last updated
2026-08-17T08:01:52.000Z

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Abstract

To our knowledge, this model is the first to characterise and predict the time-course of responses of clinical isolates to antibiotics only by the resistance mechanisms present and their complex interplay, representing a step towards pathogen-specific, personalised medicine.