Infectious Disease
Microbiology · Bugs & Drugs — Didactic Med
Microbiology — Bugs & Drugs
Open toolClinicLens specialt
Infectious Disease
136 items automatically indexed in this specialt.
← Back to all specialtiesInfectious Disease
Beyond Coverage: A Systematic Review and Thematic Analysis of Delivery, Compliance, Equity and Impact in Mass Deworming for Soil-Transmitted Helminths. | Clinic
Soil-transmitted helminth (STH) infections affect approximately 1.5 billion people globally. Although the World Health Organization (WHO) aims for 75% mass drug administration (MDA) coverage by 2030, the long-term population benefit remains debated. This review aims to describe t
Open articleInfectious Disease
Prevalence and Clinical Impact of Multidrug-Resistant Bacterial Colonization and Infection in Liver Transplant Recipients: A Systematic Review and Meta-Analysis
To our knowledge, a systematic review that has comprehensively evaluated the prevalence and clinical impact of multidrug -resistant bacteria in adult liver transplant recipients is not available. This review assessed the prevalence and clinical impact of multidrug -resistant bact
Open articleInfectious Disease
[Comment] Temocillin as a carbapenem-sparing option for ESBL bloodstream infection | ClinicLens
Antimicrobial resistance is a global threat to public health, already associated with more than 1 million attributable deaths per year; Enterobacterales, including Escherichia coli, are the pathogens responsible for the largest numbers of these antimicrobial resistance-associated
Open articleInfectious Disease
[Comment] Hantavirus: the need for a rapid regional response platform in Latin America | ClinicLens
The hantavirus cluster in 2026 linked to the MV Hondius highlights persistent gaps in global pandemic preparedness as well as weak surveillance and coordinated response capacities in Latin America. Although epidemiologically distinct from COVID-19, this event underscores the poor
Open articleInfectious Disease
[World Report] Cyclospora in the USA: why is it so hard to stop? | ClinicLens
The epidemiological challenges of the parasite have been compounded by recent cutbacks at US health agencies. Susan Jaffe reports from Washington DC.
Open articleInfectious Disease
[World Report] Cambodia reaches HIV milestone | ClinicLens
Cambodia is the first country in the Asia–Pacific to reach the 95–95–95 targets. There is hope that other countries might learn from its success. Sima Barmania reports from Bangkok and Phnom Penh.
Open articleInfectious Disease
[Correspondence] How definitions shape obesity-attributable death estimates | ClinicLens
Solja T Nyberg and colleagues1 report a consistent dose–response association between adult obesity and severe infections across Finnish cohorts and UK Biobank, and estimate that worldwide 8·6% (95% CI 6·6–11·1) of infection-related deaths in 2018, 15·0% (12·8–17·4) in 2021, and 1
Open articleInfectious Disease
[Articles] Temocillin versus carbapenems for bacteraemia due to third-generation cephalosporin-resistant Enterobacterales in Spain (ASTARTÉ): a multicentre, pha
In patients with bacteraemia caused by 3GCR-E, temocillin was non-inferior to carbapenems as targeted treatment. These findings support the use of temocillin as an effective and safe alternative to carbapenems in this setting.
Open articleInfectious Disease
[Viewpoint] Hepatitis A prevention in the USA depends on routine universal childhood vaccination | ClinicLens
On Jan 5, 2026, the Acting Director of the US Centers for Disease Control and Prevention (CDC) signed a decision memorandum from the heads of the National Institutes of Health, the Centers for Medicare & Medicaid Services, and the US Food and Drug Administration, which remove
Open articleInfectious Disease
[Editorial] Our twenty-five year journey | ClinicLens
This August issue marks the 25th anniversary of The Lancet Infectious Diseases. The journal was created in 2001 by our late Editor-in-Chief John McConnell whose vision for a journal for specialists in infectious diseases that could inform public health decisions and clinical prac
Open articleInfectious Disease
[Comment] Sense and susceptibility: predicting influenza dynamics from immune landscapes | ClinicLens
Epidemiology has been defined as “the careful definition of a numerator and a denominator” (Alexander Langmuir, founder of the US Centers for Disease Control and Prevention's Epidemic Intelligence Service). Serology has the potential to reveal an otherwise hidden denominator
Open articleInfectious Disease
[Comment] New chapter in rabies vaccine development | ClinicLens
It has been more than 140 years since Pasteur, Vulpian, and Grancher conducted the first successful human immunisation against rabies with a live-attenuated vaccine derived from dried rabid rabbit spinal cord material. The current modern purified cell culture and embryonated egg-
Open articleInfectious Disease
[Comment] Clinical trial priorities, adaptive strategies, and equitable partnerships for the Bundibugyo Ebola outbreak | ClinicLens
The ongoing outbreak of Bundibugyo virus disease in the Democratic Republic of the Congo and Uganda exposes a recurrent weakness in filovirus preparedness: clinical research systems are still too often activated after, rather than before, epidemics accelerate.1,2 Unlike disease c
Open articleInfectious Disease
[Comment] Bundibugyo Ebola in DR Congo and Uganda: community-centred response must be operational, not rhetorical | ClinicLens
On May 15, 2026, the Ministry of Public Health, Hygiene and Social Welfare of DR Congo declared the country's 17th recorded Ebola disease outbreak after the Institut National de Recherche Biomédicale confirmed Bundibugyo virus (species Orthoebolavirus bundibugyoense) as the
Open articleInfectious Disease
[Comment] The Bundibugyo virus disease outbreak: a warning signal for risks to health workers | ClinicLens
The ongoing outbreak of Ebola virus disease caused by Bundibugyo virus in DR Congo and Uganda is a reminder that epidemic preparedness remains weak, particularly where it matters most—at the front line. The outbreak was declared a Public Health Emergency of Continental Security a
Open articleInfectious Disease
[Correspondence] Rapid recruitment for a remote long COVID clinical trial | ClinicLens
There have been few long COVID clinical trials relative to the burden of disease,1 and even fewer have been accessible to people with more severe illness.2 As a person who has had moderate-to-severe long COVID (depending on the day) since 2020, I have long advocated for at-home a
Open articleInfectious Disease
[Correspondence] Tuberculosis treatment with early detection | ClinicLens
Recently, I was working in a densely populated informal settlement in Mumbai, a metropolitan city in India, where tuberculosis was a daily finding in my outpatient department due to the high endemicity. One case, however, stayed with me.
Open articleInfectious Disease
[Correspondence] The limb-saving power of bedside Gram staining | ClinicLens
As infectious disease physicians, we rarely have a single dramatic procedure that instantaneously changes a patient's trajectory: no emergent catheterisation for acute myocardial infarction, no urgent endoscopy for torrential upper gastrointestinal bleeding. Antibiotics can
Open articleInfectious Disease
[Correspondence] Keep antibiotics habitable: stewardship as climate mitigation | ClinicLens
Friends and family kept asking, “Why infectious diseases?” Although their intent was kind, the subtext was constant: why choose a path that is demanding, less lucrative, and often unseen? I had no slogan in response. I only knew that, since adolescence, I was drawn to infections
Open articleInfectious Disease
[Correspondence] 25 years of antibiotics: from desperate access to precision safety | ClinicLens
As The Lancet Infectious Diseases approaches its 25-year anniversary, your Editorial1—and its call for stories of success, hope, and inspiration—resonated strongly with our team. In our intensive care unit (ICU), one such story began with an uncomfortable series of questions at t
Open articleInfectious Disease
[Correspondence] The optimism in front of us | ClinicLens
The world often feels dark when seen through today's headlines. Conflict, division, mistrust, and crisis compete for attention.1 However, working and training in infectious diseases offers a different daily perspective. Infection does not recognise age, gender, ethnicity, re
Open articleInfectious Disease
[Correspondence] Crossing the regulatory and clinical operational valley in antimicrobial resistance: from a start-up's perspective | ClinicLens
The milestone that gave me the greatest satisfaction last year was not a headline-grabbing breakthrough, but the quiet alignment of two parallel worlds: regulatory clearance and operational readiness for BWC0977, a novel dual-targeting inhibitor of DNA gyrase and topoisomerase IV
Open articleInfectious Disease
[Correspondence] A new era of hope: the impact of long-acting injectables for individuals ageing with childhood HIV | ClinicLens
HIV carries an unwarranted stigma especially in perinatal and prepubescent populations.1 Thanks to the introduction of antiretroviral therapy (ART) during pregnancy, the rate of perinatal HIV transmission has decreased from 20–30% to 0·1–0·5%.2,3 In 2022, nearly 13 000 people in
Open articleInfectious Disease
[Correspondence] A defining clinical moment during the COVID-19 pandemic in Nigeria | ClinicLens
Moments that shape careers in infectious diseases are often rooted in uncertainty but clarified by experience. After passing my part one fellowship examination in internal medicine in May 2019, I remained undecided about whether to pursue a career in nephrology or in infectious d
Open articleInfectious Disease
[Corrections] Correction to Lancet Infect Dis 2026; published online June 2. https://doi.org/10.1016/S1473-3099(26)00194-5 | ClinicLens
GBD 2023 Diarrhoeal Disease and Enteric Infectious Diseases Collaborators. Global burden of enteric infectious diseases, diarrhoeal diseases, and corresponding aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023. Lancet Infect Dis 2026; publi
Open articleInfectious Disease
[Corrections] Correction to Lancet Infect Dis 2026; published online June 3. https://doi.org/10.1016/S1473-3099(26)00285-9 | ClinicLens
Tortosa F, Santamaría G, Bustamante R, et al. Use of tocilizumab for severe hantavirus pulmonary syndrome: a MEURI case series with contextual comparisons. Lancet Infect Dis 2026; published online June 3. https://doi.org/10.1016/S1473-3099(26)00285-9—In this Article, Ariel Izcovi
Open articleInfectious Disease
[Newsdesk] Indigenous Australians see surge in diphtheria cases | ClinicLens
An outbreak of diphtheria in Australia is predominantly affecting remote Indigenous communities of the Northern Territory and Western Australia. Tony Kirby reports.
Open articleInfectious Disease
[Newsdesk] Trials of medical countermeasures to begin in DR Congo | ClinicLens
Three drugs for Bundibugyo virus treatment and prevention are set to be tested in DR Congo under a previously established protocol for an adaptive platform trial. Esther Nakkazi reports.
Open articleInfectious Disease
[Newsdesk] Rollout of lenacapavir begins in South Africa | ClinicLens
Rollout of lenacapavir in South Africa, supported by the Global Fund, began on June 5, 2026, but activists argue that funding for doses is insufficient to make a difference. Ed Holt reports.
Open articleInfectious Disease
[Newsdesk] Cold-chain vehicles to support vaccination in Ecuador | ClinicLens
In May, 2026, Ecuador became the first country in Latin America and the Caribbean to procure vaccine-transport vehicles with cold-chain technology. Sanjeet Bagcchi reports.
Open articleInfectious Disease
[Newsdesk] 2026 High-Level Meeting on HIV/AIDS | ClinicLens
The 2026 High-Level Meeting on HIV/AIDS was hosted by the UN General Assembly in New York City, NY, USA, from June 22 to 23, 2026. Talha Burki reports.
Open articleInfectious Disease
[Profile] Krutika Kuppalli—containing infectious disease outbreaks | ClinicLens
In 2014, Krutika Kuppalli served as Medical Director of a large Ebola Treatment Unit (ETU) in Sierra Leone during the West African Ebola virus disease epidemic (2013–16). “It was the most challenging but transformative experience of my life. Even 12 years later, I am learning fro
Open articleInfectious Disease
[Media Watch] The market for pox remedies | ClinicLens
“When it came to treating the pox, misery was recast as absolution”, explains Olivia Weisser in The dreaded pox: sex and disease in early modern London, her accomplished account of venereal disease in seventeenth and eighteenth century London. At that time, the assumption was tha
Open articleInfectious Disease
[Articles] Measuring population immunity against influenza using individual antibody titres: a multicountry, retrospective observational study | ClinicLens
We developed and validated four complementary population immunity estimators derived from individual antibody titres that showed predictive utility for influenza subtype dominance and epidemic size direction across diverse settings. These estimators could inform seasonal influenz
Open articleInfectious Disease
[Editorial] “A world on the edge” as preparedness hopes waver | ClinicLens
A year ago, we expressed cautious hope at the adoption of the WHO Pandemic Agreement during the 78th World Health Assembly, with the caveat that strengthening local health systems, international cooperation, and establishing sustainable financing mechanisms would be indispensable
Open articleInfectious Disease
[Comment] From paediatric rebound to adult redistribution: changing the epidemiology of group A Streptococcus after COVID-19 | ClinicLens
The post-pandemic epidemiology of Streptococcus pyogenes has largely been interpreted through the lens of the 2022–23 upsurge, when the incidence of scarlet fever and invasive group A Streptococcus (iGAS), increased across several European countries, particularly among children.
Open articleInfectious Disease
[Comment] China lists severe fever with thrombocytopenia syndrome as a notifiable disease: a crucial step forward | ClinicLens
Severe fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV, family Phenuiviridae), is a viral haemorrhagic fever with a case-fatality rate (CFR) exceeding 10%.1 First identified in central China in 2009, SFTSV now has the broadest geographical distribution am
Open articleInfectious Disease
[Comment] Tuberculosis needs a multidimensional definition to spur thinking and action | ClinicLens
Dorland’s Medical Dictionary defines tuberculosis as any of the infectious diseases caused by species of Mycobacterium and characterised by tubercle formation with caseous necrosis in the tissues.1 Similar microbe-centric definitions that leave many questions about epidemiology,
Open articleInfectious Disease
[Correspondence] Convergence of hypervirulence and multidrug resistance driven by plasmid hybridisation and insertion sequence-mediated chromosomal integration
The convergence of hypervirulence and multidrug resistance (MDR) traits in Klebsiella pneumoniae has dramatically accelerated over the past decade, highly challenging the health-care network.1 Current evidence suggests that the convergence is primarily driven by the acquisition o
Open articleInfectious Disease
[Correspondence] Clinically dominant AbST23 iuc3 plasmids are widespread in animal-derived Klebsiella pneumoniae | ClinicLens
We read with interest the Article published in The Lancet Microbe by Marjorie J Gibbon and colleagues.1 Despite the clinical importance of iuc3-harbouring virulence plasmids in invasive human disease, genomic evidence from animal reservoirs remains inadequate worldwide, underscor
Open articleInfectious Disease
[Correspondence] Shift in pre-existing antibiotic heteroresistance explains change in antimicrobial susceptibility status from susceptible to resistant during p
Development of bacterial resistance during antibiotic therapy can lead to treatment failure and negative outcomes, including death. Although the development of resistance is observed relatively frequently, paradoxically, it is often thought to be mediated by rare mutations (frequ
Open articleInfectious Disease
[Correspondence] Improving prediction of future Mycoplasma pneumoniae epidemics using data-driven transmission models | ClinicLens
Following the global re-emergence of Mycoplasma pneumoniae infections in 2023–24 after the COVID-19 pandemic,1 a key question is when, and to what extent, these infections will surge in the near future. This question is particularly relevant because the most recent epidemic place
Open articleInfectious Disease
[News] WHO prequalifies novel polio vaccine | ClinicLens
On Feb 10, 2026, WHO prequalified a novel oral polio vaccine type 2 (nOPV2; Biological E [BioE], India). The product was developed following a technology transfer from PT Bio Farma (Indonesia). Designed to address outbreaks of circulating vaccine-derived poliovirus type 2 (cVDPV2
Open articleInfectious Disease
[News] WHO's new influenza vaccine recommendations | ClinicLens
On Feb 27, 2026, WHO released its recommendations for the composition of the influenza vaccines for the 2026–27 season in the northern hemisphere. These recommendations are issued twice a year, once for each hemisphere, after a consultation process that centres on an analysis of
Open articleInfectious Disease
[Articles] VRON-0200 alone and in combination with investigational antivirals for participants with chronic hepatitis B virus infection receiving stable nucleos
VRON-0200 alone or with investigational antiviral agents had no observed safety concerns and was well tolerated. Despite not targeting HBsAg, a single VRON-0200 dose induced broad and sustained anti-HBV immunity in most participants. When combined with antivirals, rapid and profo
Open articleInfectious Disease
[Articles] Gene transfer from NDM-5-producing and OXA-48-producing Enterobacter hormaechei ST79 on contaminated dicloxacillin capsules to other Enterobacterales
This study describes how a clonal CPE outbreak caused by a contaminated medicine evolved into a complex plasmid-mediated outbreak involving multiple Enterobacterales species. Most patients related to the outbreak did not present with the original E hormaechei ST79 outbreak strain
Open articleInfectious Disease
[Articles] Real-world emergence of nirsevimab resistance in breakthrough infections with respiratory syncytial virus-B: a multicentre observational study in Fra
Resistance to nirsevimab in RSV-B can emerge in real-world settings, affecting around 12% of breakthrough infections and showing greater diversity than previously recognised, although the clinical impact remains constrained by available evidence. Detection of resistant variants l
Open articleInfectious Disease
[Articles] Upsurge of pneumococcal clade I-α/CC180 serotype 3 and its association with a LytA mutation linked to immune evasion and disease potential: an observ
Our findings confirm that PCV13 reduced IPD cases caused by the susceptible CC260 lineage until CC260 was replaced by the clade I-α/CC180 lineage, which has a higher potential to cause IPD and divert the host immune system. A key mutation on LytA protein was associated with this
Open articleInfectious Disease
[Articles] Antimicrobial susceptibility patterns of Neisseria gonorrhoeae across anatomical sites within and between individuals in the Netherlands: a retrospec
These findings suggest that higher resistance levels observed at the population level may reflect between-person variation rather than consistent within-person anatomical-site differences. Approximately 10% of individuals showed within-person MIC discordance, potentially leading
Open articleInfectious Disease
[Articles] Evaluating the use of the first WHO International Standard for anti-SARS-CoV-2 immunoglobulin to harmonise the readouts between commercial SARS-CoV-2
These findings provide proof-of-concept evidence that for the biologically important SARS-CoV-2 spike protein, levels of anti-RBD, S1, or spike IgG binding antibodies can successfully be compared across a range of well validated commercial assays with different designs and format
Open articleInfectious Disease
[Articles] Accuracy of rapid diagnostic tests for Strongyloides stercoralis detection: a systematic review and meta-analysis | ClinicLens
Overall, RDT performance was in line with that indicated in the TPP. Hence, their further development for commercialisation for use in a public health context seems consonant. However, as part of this way forward, further research should support these results with properly design
Open articleInfectious Disease
[Review] Diagnostics for priority bacterial pathogens: global gaps and research needs for curbing antimicrobial resistance in low-resource settings | ClinicLens
Antimicrobial resistance (AMR) is a major and growing threat to global health, development, and security, with the greatest burden borne by low-income and middle-income countries (LMICs). Without urgent intervention, cumulative deaths between 2020 and 2050, attributable to AMR, a
Open articleInfectious Disease
[Personal View] The diagnostic void: how typhoid-by-default drives antimicrobial resistance in Ethiopia | ClinicLens
The empirical diagnosis of typhoid-by-default represents a severe failure in Ethiopia’s management of febrile illnesses. This practice of diagnosing undifferentiated fever as typhoid without confirmation drives antimicrobial resistance (AMR) through a unique diagnostic ecosystem
Open articleInfectious Disease
Field evaluation of 3-(N-acetyl-n-butyl) aminopropionic acid ethyl ester - IR3535 as a spatial repellent to control malaria: A Randomised, Before-After-Control-
Malaria remains a major public health challenge in sub-Saharan Africa. Increasing mosquito resistance to insecticides can significantly limit current vector control strategies. Spatial repellents represent a promising complementary tool by disrupting mosquito human-seeking behavi
Open articleInfectious Disease
Assessing the relationship between body mass index and influenza-like illness risk and symptom severity among military health system beneficiaries vaccinated ag
Obesity prevalence is rising globally and associated with increased influenza mortality. The relationship between obesity and influenza-like-illness (ILI) incidence and symptom severity is less clear. US Military Health System (MHS) beneficiaries enrolled in a randomized influenz
Open articleInfectious Disease
Assessing the prevalence of anosmia and taste dysfunction in COVID-19 patients in Saudi Arabia: a systematic review and meta-analysis. | ClinicLens
Patients with coronavirus disease-2019 (COVID-19) frequently report olfactory and gustatory dysfunctions, including anosmia and ageusia. Multiple studies have assessed the prevalence of these symptoms in COVID-19 patients in Saudi Arabia. This systematic review and meta-analysis
Open articleInfectious Disease
Crimean-Congo hemorrhagic fever in Iran: a systematic review of viral detection in ticks, vector distribution, and data gaps for health system decision-makers.
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral zoonosis reported in Iran, where hard ticks serve as both reservoirs and vectors for Crimean-Congo hemorrhagic fever virus (CCHFV). Understanding the geographic distribution and infection prevalence in tick populations
Open articleInfectious Disease
Sarcopenic Obesity in People With HIV: Diagnostic Criteria and Classification-A Scoping Review With a Meta-Analysis of Prevalence. | ClinicLens
(a) To describe studies that evaluated sarcopenic obesity (SO) in people with HIV (PWH); (b) to summarize the methods and diagnostic criteria used to define SO in PWH; and (c) to estimate the overall prevalence of SO in this population. Scoping review conducted according to estab
Open articleInfectious Disease
Individual-level HPV vaccination verification in Botswana: lessons learned from implementation of the HOPE II trial. | ClinicLens
The World Health Organization (WHO) estimated 660,000 new cervical cancer cases and 350,000 deaths globally in 2022, with over 90% occurring in low- and middle-income countries (LMICs). Global elimination targets call for vaccination of >90% of girls against human papillomavir
Open articleInfectious Disease
Digital Training for Lay Health Care Workers' Knowledge and Skills in HIV Index Case Testing: Cluster Randomized Trial. | ClinicLens
Task shifting in low-resource settings requires lay health care workers (HCWs) to provide a variety of health services, such as HIV index case testing, whereby sexual partners and family members of people living with HIV are offered HIV testing. For this, lay HCWs require adequat
Open articleInfectious Disease
Meningococcal B Vaccine to Prevent Neisseria gonorrhoeae Infection. | ClinicLens
No vaccines are currently licensed for the prevention of Neisseria gonorrhoeae infection. Observational studies suggest that the four-component meningococcal serogroup B vaccine (4CMenB) may reduce the risk of gonorrhea. In this multicenter, double-blind, randomized, placebo-cont
Open articleInfectious Disease
A novel design using a virtual control group to evaluate non-inferiority of nevirapine and lamivudine dual maintenance in HIV therapy. | ClinicLens
Reducing the number of drugs in combined antiretroviral therapy (cART) likely reduces toxicity. We hypothesized that dual therapy (DT) with nevirapine (NVP) and lamivudine (3TC) would be non-inferior to a virtual control without treatment failure. This multicenter study enrolled
Open articleInfectious Disease
Bispecific 10E8.4/iMab broadly neutralizing antibody in people with or without HIV-1: a partially randomized phase 1 trial. | ClinicLens
Broadly neutralizing antibodies (bnAbs) are a promising tool for HIV prevention and treatment. Here we conducted a first-in-human, phase 1 trial of the bispecific 10E8.4/iMab antibody, which consists of a 10E8.4 arm binding the HIV-1 envelope glycoprotein membrane-proximal extern
Open articleInfectious Disease
Frailty phenotype transitions and functional improvements during a supervised exercise trial in older people with HIV: results from the HEALTH Trial. | ClinicLe
Frailty and sarcopenia contribute to functional decline in older people with HIV (PWH), yet intervention data remain limited. We evaluated changes in frailty phenotype status, sarcopenia-related outcomes and functional performance during a supervised exercise trial and assessed a
Open articleInfectious Disease
Efficacy of the 4CMenB vaccine against gonorrhea among men who have sex with men in Hong Kong: A double-blind randomized placebo-controlled trial. | ClinicLens
The emergence of antimicrobial-resistant gonorrhea among men who have sex with men (MSM) demands new prevention strategies. This study aimed to assess the efficacy of the four-component meningococcal group B (4CMenB) vaccine against gonorrhea among MSM. A prospective, randomized,
Open articleInfectious Disease
HIV Care Retention and Cost Analysis in Multi-Month ART Dispensing: A Randomized Controlled Trial in China. | ClinicLens
Multi-month dispensing (MMD), as a differentiated service delivery model, can reduce the frequency of clinic visits, waiting time and travel costs for clinically stable people living with HIV. This study aimed to evaluate the impact of 6-month MMD of antiretroviral therapy (ART)
Open articleInfectious Disease
Impact of motivational interviewing training for lay counsellors on HIV care outcomes in South Africa: a cluster-randomized pilot trial. | ClinicLens
Retention in HIV care remains challenging in sub-Saharan Africa. We evaluated whether training lay counsellors in Motivational Interviewing (MI) could improve outcomes among newly diagnosed people living with HIV (PLHIV) in South Africa. We conducted a cluster-randomized pilot tr
Open articleInfectious Disease
Acceptability of a Dolutegravir Oral Dispersible Film in Term Neonates Born to Mothers Living With HIV. | ClinicLens
Dolutegravir (DTG) is a key antiretroviral (ARV) drug for children living with HIV, but no specific formulation is available for neonates (<28 days old). One of the DTG formulations evaluated in the PETITE-DTG trial was a novel 5 mg oral DTG dispersible film (DTG-Film). Accept
Open articleInfectious Disease
A Urine Tenofovir Point-of-Care Assay Facilitates Positive Antiretroviral Therapy Adherence Discussions Among People Living With HIV and Healthcare Providers-A
In South Africa, antiretroviral therapy adherence monitoring relies on self-reported adherence, which is prone to recall error, and only verified annually during blood viral load measurement. A novel urine tenofovir rapid assay (UTRA) is a low-cost point-of-care adherence support
Open articleInfectious Disease
The effect of podcasts delivered to female university students on HPV knowledge, awareness, and anxiety levels: A randomized controlled trial. | ClinicLens
The aim of this study was to evaluate the effect of podcast-based educational content delivered to students on their knowledge, awareness and anxiety levels regarding Human Papillomavirus (HPV). This randomized controlled experimental study was conducted between 7 April 2025 and
Open articleInfectious Disease
Immunogenicity and safety of co-administered Escherichia coli-produced bivalent HPV-16/18 vaccine and hepatitis E vaccine. | ClinicLens
Human papillomavirus (HPV) and Hepatitis E virus (HEV) infections are major health concerns for women of reproductive age. Administration of HPV and HEV vaccines serves as primary prevention strategies. Our study aimed to demonstrate the immunogenicity and safety of co-administer
Open articleInfectious Disease
Impact of Nutrition Education on Nutrition Knowledge, Attitudes, Practices, and Immune-Related Nutrient Intake in People Living with HIV: A Randomized Controlle
Objective: Nutrition is critical for people living with human immunodeficiency virus (PLHIV); nonetheless, nutritional interventions have not been conducted among PLHIV in the Middle East and North Africa region. This study evaluated the effects of a nutrition-related education i
Open articleInfectious Disease
Fluoroquinolones versus doxycycline in the treatment of rickettsial infection: A Tunisian multicenter prospective study. | ClinicLens
Doxycycline is considered as the standard treatment of rickettsiosis.Fluoroquinolones used as an alternative therapy, until recent studies have shown that Fluoroquinolones are associated with a deleterious outcome Objectives : To compare therapeutic efficacy and safety of fluoroq
Open articleInfectious Disease
Subgingival air polishing (glycine powder) versus minocycline hydrochloride: efficacy in residual periodontal pockets following endoscope-assisted scaling and r
To evaluate the effects of subgingival air polishing (glycine powder) or minocycline hydrochloride on periodontal parameters and inflammatory levels in residual periodontal pockets following periodontal endoscope-assisted scaling and root planing. This single-center, randomized c
Open articleInfectious Disease
Patient experiences and motivations in tuberculosis treatment: Insights from a digital adherence technology trial. | ClinicLens
Non-adherence to Tuberculosis (TB) treatment remains a global health challenge, particularly in low- and middle-income countries. Digital Adherence Technologies (DATs) have shown promise in improving treatment outcomes, yet little is known about user perceptions. Through an exit
Open articleInfectious Disease
Eliminating Inappropriate Postoperative Antibiotics: A Stepped-Wedge Cluster Randomized Trial. | ClinicLens
Unnecessary postoperative antibiotic use is common. This study evaluated whether modifying electronic health record order sets plus participation in a facilitation workshop by the antimicrobial stewardship team reduced inappropriate postoperative antibiotic duration more than mod
Open articleInfectious Disease
Temocillin versus carbapenems for bacteraemia due to third-generation cephalosporin-resistant Enterobacterales in Spain (ASTARTÉ): a multicentre, phase 3, open-
Alternatives to carbapenems for the treatment of third-generation cephalosporin-resistant Enterobacterales (3GCR-E) are urgently needed to reduce the selection pressure posed by these drugs. Temocillin is a neglected narrow-spectrum β-lactam. The aim of the trial was to investiga
Open articleInfectious Disease
[Is there an alternative to antibiotics in patients with cystitis?]. | ClinicLens
Approaches to the treatment of cystitis have changed in recent years. Although the benefit of antibiotics in urinary tract infection is evident, excessive and inappropriate use has contributed to increased antimicrobial resistance among uropathogens and a higher rate of adverse e
Open articleInfectious Disease
[A double-blind, randomized, placebo-controlled, multicenter clinical trial of the efficacy and safety of oral enzyme combination in the complex treatment of pa
The treatment of recurrent lower urinary tract infections (RLUTIs) remains unresolved due to increasing antibiotic resistance and the ability of pathogens to form biofilms and parasitize intracellularly, creating microbial communities with biofilm-like properties. Therefore, grea
Open articleInfectious Disease
Procalcitonin to Guide 7 vs 14 Days of Antibiotics in Bloodstream Infections: A Secondary Analysis of the BALANCE Trial. | ClinicLens
The Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE) trial showed that 7 days of antibiotics was noninferior to 14 days among patients with bacteremia. However, it is unknown whether patients with high serum procalcitonin (PCT) level at day 7 of t
Open articleInfectious Disease
Four-Week vs Six-Week Antibiotic Therapy in the Management of Nonsurgically Treated Diabetic Foot Osteomyelitis: Protocol for a Multicentric, Single-Blind Rando
Diabetic foot osteomyelitis (DFO) is a common complication and major cause of morbidity among people with diabetes mellitus. There has been growing acceptance of primarily nonsurgical (conservative) management of DFO based on antibiotics alone. However, the most appropriate durat
Open articleInfectious Disease
A Pragmatic Trial of a 6-Month Strategy for Rifampicin-Resistant Tuberculosis. | ClinicLens
Safer, more effective treatment regimens for rifampicin-resistant tuberculosis are needed. We conducted a phase 3, open-label, pragmatic, randomized, controlled noninferiority trial in South Africa to assess a 6-month treatment strategy for pulmonary rifampicin-resistant tubercul
Open articleInfectious Disease
Safety of antibiotic audit and feedback: secondary analysis of a randomized controlled trial. | ClinicLens
We previously demonstrated in a randomized controlled trial that antibiotic prescribing feedback to family physicians reduced antibiotic use. However, that trial did not evaluate for patient harms from potential under-prescribing of antibiotics. To evaluate the safety of an antib
Open articleInfectious Disease
Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug-Resistant Tuberculosis. | ClinicLens
Pretomanid is a component of the World Health Organization-recommended treatment regimen for drug-resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no correspond
Open articleInfectious Disease
Therapeutic monitoring of beta-lactams in critically ill patients with sepsis: Clinical trial protocol. | ClinicLens
Sepsis is a leading cause of morbidity and mortality among hospitalized patients and is associated with intensive use of β-lactam antibiotics. These drugs show time-dependent pharmacodynamics and high pharmacokinetic variability in this population, making it difficult to achieve
Open articleInfectious Disease
Benzylpenicillin versus flucloxacillin or cloxacillin for the treatment of penicillin-susceptible Staphylococcus aureus bacteraemia (SNAP): an international, mu
Previously considered rare, penicillin-susceptible Staphylococcus aureus (PSSA) bacteraemia has re-emerged worldwide. Although benzylpenicillin might offer advantages in terms of pharmacokinetic and adverse effect profiles, anti-staphylococcal penicillins are recommended for seri
Open articleInfectious Disease
Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia. | ClinicLens
Staphylococcus aureus bacteremia is associated with high mortality. Whether cefazolin or an antistaphylococcal penicillin should be preferred for the treatment of methicillin-susceptible S. aureus bacteremia is unclear. In an ongoing international Bayesian adaptive platform trial
Open articleInfectious Disease
Phase I dose-ascending, safety, and pharmacokinetics study of APC148, a novel metallo-β-lactamase inhibitor, in healthy volunteers. | ClinicLens
APC148 is a novel metallo-β-lactamase inhibitor with broad activity against Ambler class B enzymes, including NDM, VIM, and IMP. It is being developed for patients with serious infections caused by multidrug-resistant, gram-negative bacteria. APC148 is combined with the broad-spe
Open articleInfectious Disease
Experimental human colonisation with non-toxigenic Clostridioides difficile: a placebo-controlled randomised clinical trial. | ClinicLens
Clostridioides difficile infections remain a major global healthcare burden, underscoring the need for novel therapies. Human colonisation models provide mechanistic insight into C. difficile colonisation and facilitate identification of novel intervention targets. We conducted a
Open articleInfectious Disease
Accuracy and safety of C-TST for tuberculosis infection: A clinical trial in Brazil. | ClinicLens
Tuberculosis infection (TBI) diagnosis in BCG-vaccinated, high-burden settings remains challenging. We aimed to assess the sensitivity, specificity, and safety of the C-tuberculin skin test (C-TST), compared with PPD RT-23, for tuberculosis infection in BCG-vaccinated adults. Ran
Open articleInfectious Disease
Optimized seasonal influenza mRNA vaccine compositions demonstrate safety and enhanced immunogenicity in a phase 2 study. | ClinicLens
Seasonal influenza causes considerable morbidity and mortality, with influenza A and B viruses driving most influenza-associated hospitalizations and deaths. Vaccination remains a key influenza prevention strategy; however, current seasonal influenza vaccines based on traditional
Open articleInfectious Disease
Comparative Efficacy and Safety of 15-Valent and 13-Valent Pneumococcal Conjugate Vaccines Alone and in Combination with the 23-Valent Polysaccharide Vaccine: A
In addition to the 23-valent pneumococcal polysaccharide vaccine (PPSV23), the 13-valent and 15-valent pneumococcal conjugate vaccines (PCV13 and PCV15, respectively) are currently utilized as optional vaccines for adults. Although PCV15 provides broader serotype coverage than PC
Open articleInfectious Disease
Genotypic analysis of Plasmodium falciparum malaria parasites in a clinical trial of RTS,S vaccination in combination with seasonal malaria chemoprevention. | C
Both vaccination and seasonal chemoprevention are effective interventions against malaria, but both morbidity and mortality due to malaria remain high, particularly in sub-Saharan Africa. A recent clinical trial showed that the combination of these interventions provided substant
Open articleInfectious Disease
Safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle vaccine (CIC) containing SARS-CoV-2 recombinant spike and quadrivalent influenza hema
Based on viral evolution, increases in seasonal infections, and facilitation of delivery, an annual combination vaccine simultaneously targeting influenza and SARS-CoV-2 would benefit public health. The safety and immunogenicity of a COVID-19-Influenza Combination nanoparticle va
Open articleInfectious Disease
Randomized controlled trial evaluating immunogenicity and safety of a porcine circovirus-free rotavirus vaccine in healthy Chinese infants. | ClinicLens
Rotavirus (RV) is a leading cause of diarrhea-related morbidity and mortality among children under 5 y globally, accounting for approximately one-third of childhood diarrhea cases in China. Vaccination is the most effective strategy for RV prevention. Rotarix, a liquid RV vaccine
Open articleInfectious Disease
Bidirectional associations between influenza and COVID-19 vaccination: a systematic review and meta-analysis. | ClinicLens
This study aimed to investigate the effect of vaccination history on future willingness or behavior to receive vaccinations for influenza and COVID-19. In this systematic review and meta-analysis, the PubMed, Embase, Web of Science, Cochrane Library, APA PsycInfo, CINAHL and Scop
Open articleInfectious Disease
Implementing mass dog rabies vaccination through a community-based continuous approach: A socio-anthropological process evaluation. | ClinicLens
Mass dog vaccination to control rabies usually involves centralized planning and team-led annual campaigns. We evaluated the implementation processes of a decentralized, community-based continuous approach to mass dog vaccination (CBC-MDV), delivered as an arm of a randomized con
Open articleInfectious Disease
A phase 3, randomized study to evaluate the safety, tolerability, and immunogenicity of V116 in children and adolescents with increased risk of pneumococcal dis
Pneumococcal disease (PD) causes significant illness and death, especially in young children, older adults, and individuals with chronic medical conditions. Due to increased risk, children with chronic conditions are often advised to receive additional pneumococcal vaccination be
Open articleInfectious Disease
Immunogenicity and safety of a pentavalent meningococcal MenABCWY vaccine in healthy adolescents and young adults: a phase 3, multicountry, randomised, observer
Neisseria meningitidis serogroups A, B, C, W, and Y (MenA, Men B, MenC, MenW, and MenY) cause nearly all invasive meningococcal disease globally, and clinical outcomes are often severe. We aimed to evaluate the safety and immunological non-inferiority of a MenABCWY vaccine, compr
Open articleInfectious Disease
Effectiveness of an online vaccine misinformation game for Arabic-speaking Australians: a randomized controlled trial. | ClinicLens
Vaccine misinformation can undermine vaccine confidence, institutional trust, and uptake. Arabic speakers in Australia are disproportionately susceptible to vaccine misinformation and have experienced adverse health outcomes. This randomized controlled trial tested the effectiven
Open articleInfectious Disease
Global determinants of dengue vaccine acceptance: An updated systematic review and meta-analysis. | ClinicLens
To systematically review and quantify the key determinants influencing dengue vaccine acceptance in populations where the vaccine is recommended or considered. Systematic review and meta-analysis. Comprehensive searches were performed in PubMed, Web of Science, Global Index Medic
Open articleInfectious Disease
Neglected tropical diseases in conflict-related humanitarian emergency settings: a systematic review of the literature. | ClinicLens
Neglected tropical diseases (NTDs) are a group of 21 conditions affecting an estimated 1 billion people worldwide, causing significant mortality and morbidity. WHO has targeted their control, elimination or eradication by 2030, while highlighting that conflict and humanitarian em
Open articleInfectious Disease
Virologic insights from the phase 3 REDPINE trial: remdesivir in renally impaired and immunocompromised patients with COVID-19. | ClinicLens
Remdesivir inhibits the SARS-CoV-2 RNA-dependent polymerase (Nsp12). Here, we present virology analyses from the Phase 3 REDPINE trial in participants with impaired kidney function hospitalized for COVID-19 and treated with remdesivir or placebo for 5 days. Out of 243 participant
Open articleInfectious Disease
Association of asthma and COPD with pertussis risk: A systematic review and meta-analysis. | ClinicLens
Pertussis, caused by Bordetella pertussis, has resurged globally despite widespread childhood vaccination. With waning immunity, adolescent and adult cases have increased. Patients with asthma and chronic obstructive pulmonary disease (COPD) may be more susceptible due to chronic
Open articleInfectious Disease
Toxocara infection in children with asthma: a systematic review and meta-analysis. | ClinicLens
Evidence linking zoonotic nematode Toxocara and asthma is mounting in children. We aimed to estimate the pooled prevalence of Toxocara seropositivity in asthmatic children and quantify the association. We searched PubMed, Embase and Web of Science for studies (through 18 June 202
Open articleInfectious Disease
Social Media Messaging to Reduce HIV-Related Stigma Among Young Adults in Peru: A Randomized Controlled Study. | ClinicLens
HIV-related stigma undermines prevention and treatment efforts, particularly among young adults. Social media offers a scalable platform for stigma-reduction efforts; however, empirical evidence of its effectiveness remains limited. Social media influencers may enhance the effect
Open articleInfectious Disease
Effect of probiotics on humoral responses to COVID-19 vaccination in older adults: a randomized, placebo-controlled trial (PIRATES-COV study). | ClinicLens
Although COVID-19 vaccination has reduced morbidity and mortality, adults aged 65 y old and older are at high risk of complications from COVID-19. The evidence suggests that probiotics may enhance immune responses when co-administered with influenza vaccination. However, few stud
Open articleInfectious Disease
Evaluation of microscopically quantitative loads of bacilli as early predictors of TB treatment outcome. | ClinicLens
BACKGROUND Two-month smear conversion has been adopted instead of cultures to predict unfavourable bacteriological outcomes in TB treatment. However, this approach is limited by lower sensitivity and specificity. OBJECTIVE In absence of early-stage biomarkers of treatment respons
Open articleInfectious Disease
Using a decision support tool to reduce inappropriate antibiotic use after a delayed prescription. | ClinicLens
Antimicrobial resistance is partly driven by overprescribing antibiotics in primary care. Delayed antibiotic prescriptions, which allow patients to monitor their symptoms before deciding to use antibiotics, are a promising intervention. However, this strategy is undermined when p
Open articleInfectious Disease
Current Impact of COVID-19 in Long-Term Care Facilities in the United States: A Systematic Literature Review. | ClinicLens
Background: COVID-19 disproportionately affects older adults, placing residents of closed-community settings, such as long-term care facilities (LTCFs), at increased risk for severe illness and death. Objective: To describe the epidemiology and healthcare resource utilization ass
Open articleInfectious Disease
Inter-hospital ICU-to-ICU transfer of critically ill COVID-19 patients is not associated with increased mortality: a systematic review with exploratory meta-ana
During the COVID-19 pandemic, inter-hospital transfer of critically ill patients between intensive care units was widely used to manage capacity shortages. While several individual studies have compared outcomes of transferred and non-transferred patients, no systematic synthesis
Open articleInfectious Disease
Tracheobronchial invasion by nontuberculous mycobacteria: a rare but overlooked clinical manifestation-a multicenter retrospective analysis. | ClinicLens
Nontuberculous mycobacteria (NTM) can disseminate and infect various organs throughout the body. However, whether NTM can infect tracheobronchial tissue is rarely reported. This study aimed to address the knowledge gap regarding the epidemiological, demographic, and clinical char
Open articleInfectious Disease
WHO Issues Guidelines for Treating Ebola and Marburg Viruses | ClinicLens
The World Health Organization (WHO) released its first comprehensive guidelines on the clinical management of filovirus disease, which includes all Ebola and Marburg viruses.
Open articleInfectious Disease
The HIV Reservoir Could Be Larger Than Thought | ClinicLens
This Medical News article discusses new research that potentially expands the types of T cells known to harbor latent HIV.
Open articleInfectious Disease
Effect of Information-Video Presenter Sex on Recruitment | ClinicLens
This trial within the Danish DAN-RSV adult respiratory syncytial virus vaccine trial assesses whether the sex of the person presenting an informational video for potential trial participants is associated with trial enrollment.
Open articleInfectious Disease
Seymour Plan For Disease Prevention | ClinicLens
At the conference of State and Provincial Authorities of North America held in Atlantic City in May, Dr. M. M. Seymour, deputy minister of public health of Saskatchewan and president of the conference, proposed a plan for “drives” against diphtheria, smallpox and typhoid. In brie
Open articleInfectious Disease
Safety and antiviral activity of inhaled siRNA SNS812 for treatment of mild-to-moderate COVID-19: a phase 2 randomized trial. | ClinicLens
SARS-CoV-2 remains a global health threat because ongoing viral evolution and immune evasion reduce the effectiveness of existing therapies. SNS812 is an inhaled small interfering RNA targeting a highly conserved region of the viral RNA-dependent RNA polymerase gene, representing
Open articleInfectious Disease
Risk of Virological Failure After Switch to a Tenofovir-Sparing Dual Therapy in Virologically Suppressed People With HIV and Past HBV Infection. | ClinicLens
We compared the effectiveness of tenofovir (TFV)-based triple regimens (TT) to TFV-sparing dual therapies (DT) in virologically suppressed, HBsAg-/HBcAb+ people living with HIV (PLWH). We emulated a target trial including adults PLWH from five University Hospitals, with HBsAg-/HB
Open articleInfectious Disease
Toward Empowering Women in HIV Care: A Peer-Supported Patient-Initiated Viral Load Testing Cluster-Randomized Trial in Dar es Salaam, Tanzania. | ClinicLens
BackgroundRoutine viral load testing (VLT) is critical for monitoring HIV treatment effectiveness, yet adherence to annual testing and patient engagement remain suboptimal, particularly among women. We evaluated a peer educator-supported, patient-initiated VLT approach in Dar es
Open articleInfectious Disease
Application Effects and Optimization Strategies of Multi-Scenario Simulation Teaching in Practical Instruction of Infectious Diseases. | ClinicLens
This prospective randomized controlled trial evaluated the effectiveness of multi-scenario simulation teaching in improving practical competence among medical and nursing students during infectious disease training. A total of 121 students were randomly assigned to a simulation g
Open articleInfectious Disease
Adapting mHealth Interventions to Improve Self-Management of HIV and Reduce Substance Use Among Emerging Adults in Zambia: Protocol for a Randomized Controlled
Sub-Saharan Africa remains the region most affected by the HIV epidemic, with Zambia experiencing a substantial burden of disease. Young people with HIV are disproportionately impacted. Emerging adulthood (ages 18-24 years) is characterized by increasing independence, risk-taking
Open articleInfectious Disease
Effect of high-dose versus standard-dose influenza vaccines on hospitalisation outcomes and mortality in older adults: a systematic review and meta-analysis. |
The comparative efficacy and safety of high-dose inactivated influenza vaccine (HD-IIV) versus standard-dose inactivated influenza vaccine (SD-IIV) in adults 65 years or older remain uncertain. Hence, we aimed to compare the effects of HD-IIV versus those of SD-IIV for hospitalis
Open articleInfectious Disease
IgM-Enriched Immunoglobulin As Adjunctive Therapy in Adult Sepsis and Septic Shock: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. | Cli
To evaluate randomized adult evidence on adjunctive immunoglobulin M (IgM)-enriched immunoglobulin for sepsis and septic shock, with emphasis on short-term mortality, endpoint heterogeneity, statistical robustness, and harms reporting. MEDLINE, PubMed, Embase, CENTRAL, and Web of
Open articleInfectious Disease
Comparing adherence strategies and facility DOT in TB care: a systematic review with meta-analysis. | ClinicLens
BACKGROUND Adherence to TB treatment is crucial for successful outcomes. While facility-based directly observed therapy (FB-DOT) is a common strategy, recognition of its limitations has spurred the development of flexible approaches. We have compared the effectiveness of alternat
Open articleInfectious Disease
Co-managing the double burden: strategies for simultaneously tackling infectious and non-communicable diseases. | ClinicLens
Evidence increasingly shows close, bidirectional links between infectious diseases (IDs) and non-communicable diseases (NCDs). However, research, health policy, and prevention practices still largely address them in separate frameworks. This scoping review summarises the current
Open articleInfectious Disease
Convalescent Plasma Restores Viral Clearance After Anti-Spike Monoclonal Antibody Failure in Immunocompromised COVID-19 Patients: A Systematic Review and Meta-A
Anti-Spike monoclonal antibodies (mAbs) progressively lost efficacy during the COVID-19 pandemic due to the emergence and predominance of resistant SARS-CoV-2 variants. By contrast, high-titre COVID-19 convalescent plasma (CCP) collected from vaccinated donors recently recovered
Open articleInfectious Disease
Timing, Titre, and Host Determinants of Convalescent Plasma Efficacy in COVID-19: A Systematic Review With Design-Stratified Narrative Synthesis. | ClinicLens
The efficacy of convalescent plasma (CP) in COVID-19 has been contested, with large randomized trials producing conflicting results that led to recommendations against routine use. We performed a systematic review with design-stratified narrative synthesis (PRISMA 2020; SWiM; OSF
Open articleInfectious Disease
The use of patient-reported outcome questionnaires in patients with post-COVID-19 condition: a systematic review and meta-analysis. | ClinicLens
Post-COVID-19 condition (PCC) is a complication of acute COVID-19, which often presents with a variety of symptoms. It can also impact individuals' overall well-being, capacity to carry out daily activities, engage in physical exercise, maintain employment, and their general
Open articleInfectious Disease
Human gnathostomiasis - A systematic review and analysis of the literature. | ClinicLens
Human gnathostomiasis is a foodborne zoonotic nematode infection caused by the larval stage of Gnathostoma species. Although historically reported predominantly from Asia and America, cases are increasingly identified in previously non-endemic regions. The heterogeneous clinical
Open articleInfectious Disease
Emergence of Babesiosis in Nova Scotia, Canada. | ClinicLens
AbstractAs part of a multi-year surveillance program of tick-borne diseases, we describe babesia surveillance of blood donors using nucleic acid tests conducted in 2025 and summarize cases of babesiosis reported by public health officials in Nova Scotia, Canada, from 2023 through
Open articleInfectious Disease
Treatment of Recurrent C. difficile Infection - Making the Best Use of What We Have. | ClinicLens
Treatment of Recurrent C. difficile Infection - Making the Best Use of What We Have.
Open articleInfectious Disease
Arrhythmias in Dengue: Moving Upstream from Electrocardiographic Findings to Cardio-Hemodynamic Dysfunction. Comment on López-Delgado et al. Arrhythmias in Deng
We read with great interest the systematic review and meta-analysis by López-Delgado et al. [...].
Open articleInfectious Disease
COVID-19 cluster outbreaks and infection control measures in nursing homes in Okinawa: protocol for a retrospective observational study | ClinicLens
Introduction Following the reclassification of COVID-19 as a category V infectious disease in Japan in May 2023, systematic public health monitoring of case numbers and cluster outbreaks was discontinued. Consequently, infection control measures, responses to cluster outbreaks an
Open articleInfectious Disease
Examining the immune response of participants receiving Modified Vaccinia Ankara vaccine in Africa (MpoxVax AFRIVAC): a prospective cohort study - protocol | Cl
Introduction Mpox remains an ongoing global health concern, driven by an ongoing clade I outbreak in Central Africa, which has caused substantial morbidity and mortality. Despite deployment of the Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine, data on the durability o
Open articleInfectious Disease
Feasibility and acceptability of pooled sputum testing for tuberculosis: a multicountry qualitative study of the Start4All project | ClinicLens
Objectives Tuberculosis (TB) remains underdiagnosed in many high-burden countries due to high costs and limited availability of rapid molecular tests. Globally, only half of people with TB receive a molecular test as their initial diagnostic test. Pooled testing combines sputum s
Open article