Neurology
Mental Disorders Special Edition - Clinical Cases by Didactic Med
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Phase 2b Trial of a NaV1.8 Inhibitor for Acute Pain. | ClinicLens
Nav1.8, a voltage-gated sodium channel expressed in the peripheral nervous system, has a critical role in pain signaling. Previous trials of NaV1.8 inhibitors have shown effectiveness in reducing postoperative pain. We conducted a phase 2b, double-blind, randomized, placebo-contr
Open articleNeurology
Time course of motor recovery after stroke with and without levodopa: a post hoc 6-month longitudinal analysis of the ESTREL trial. | ClinicLens
Levodopa did not enhance early motor recovery at 3 months after stroke in the Enhancement of Stroke Rehabilitation with Levodopa (ESTREL) trial. However, whether levodopa modifies the time course of recovery, leading to a delayed benefit remains unclear. Here, we examined levodop
Open articleNeurology
Impact of a Staged Enteral Nutrition Nursing Pathway Based on Dynamic Assessment of Tolerance and Aspiration Risk vs Usual Care on Feeding Intolerance in Older
BACKGROUND Older adult patients with acute ischemic stroke have dysphagia and require early post-pyloric enteral nutrition, yet feeding intolerance and unstable energy delivery remain common, and practical pathways that integrate tolerance and aspiration risk are lacking. This tr
Open articleNeurology
Combining Pulsed Radiofrequency With Transcranial Magnetic Stimulation to Manage Hemiplegic Shoulder Pain and Somatosensory Nerve Transmissions. | ClinicLens
Hemiplegic shoulder pain (HSP) is a major cause of disability that is still challenging to manage in clinical practices. Both pulsed radiofrequency (PRF) and repetitive transcranial magnetic stimulation (rTMS) could reduce poststroke HSP to certain extents. However, it remains un
Open articleNeurology
Feasibility of the Italian version of the Teen Online Problem Solving Program (I-TOPS) in a sample of adolescents with acquired brain injury: Results from a ran
Numerous neurocognitive and behavioral deficits in adolescents with acquired brain injury have been associated with impairments in executive functions. Nevertheless, many adolescents do not receive targeted rehabilitation. One of the most validated interventions addressing execut
Open articleNeurology
Alzheimer's blood-based biomarkers, incident dementia, and interactions with age, APOE status, and hormone therapy. | ClinicLens
Cognitive impairment among older adults is often due to multiple pathologies and heterogenous risk factors. We assessed whether Alzheimer's blood-based biomarkers (BBMs) were associated with incident mild cognitive impairment (MCI)/probable dementia, and whether associations
Open articleNeurology
Effects of repetitive peripheral magnetic stimulation on poststroke ankle spasticity: a double-blind randomized controlled trial. | ClinicLens
Repetitive peripheral magnetic stimulation (rPMS) is a noninvasive, painless therapy aimed at improving spasticity, with a proposed mechanism that involves neuromodulation through somatosensory and proprioceptive afferent stimulation. The present study evaluates the effectiveness
Open articleNeurology
Theta tACS Over the Medial Frontal Cortex Modulates Executive Function in Parkinson's Disease: A Randomized, Sham-Controlled Study. | ClinicLens
Executive dysfunction is a common non-motor symptom of Parkinson's disease (PD) and has been linked to dysfunction of the medial frontal cortex (MFC). This randomized, sham-controlled study investigated whether high-definition transcranial alternating current stimulation (HD
Open articleNeurology
Effect of vitamin D supplementation on clinical outcomes of patients with Parkinson disease: A randomized controlled study. | ClinicLens
Vitamin D deficiency is linked to Parkinson disease (PD) pathogenesis; however, clinical trial results remain inconclusive. Thus, in this study, we aimed to evaluate the prevalence of vitamin D deficiency in Thai patients with PD and the efficacy of vitamin D3 supplementation on
Open articleNeurology
Effects of the Digital App "Support, Monitoring and Reminder Technology for Mild Dementia" (SMART4MD) on People With Mild Cognitive Impairment and The
Previous research has shown that mobile health (mHealth) interventions are effective in reminding older adults with chronic conditions about health care appointments and promoting adherence to medication schedules. However, the evidence is limited by the short duration and poor q
Open articleNeurology
Impact of prior intravenous thrombolysis on first-line thrombectomy strategy. A secondary analysis of the VECTOR trial. | ClinicLens
Whether prior intravenous thrombolysis (IVT) modifies the relative efficacy of first-line thrombectomy strategies remains uncertain, and no randomised trial has specifically addressed this question. Leveraging the randomised design of the VECTOR trial, a multicentre trial compari
Open articleNeurology
Efficacy and Mechanisms of Combined Central-Peripheral Magnetic Stimulation on Prefrontal-Sensorimotor Cortex Connectivity in Post-Stroke Dysphagia after Suprat
Combined central-peripheral magnetic stimulation shows promise for post-stroke dysphagia (PSD), but its neural mechanisms remain unclear. We evaluated the its efficacy and cortical mechanisms in PSD patients. In this single-blind, parallel-controlled trial, 44 PSD patients were r
Open articleNeurology
Application of gastric tube removal strategy based on the combination of Gugging Swallowing Screen (GUSS) and National Institutes of Health Stroke Scale (NIHSS)
Dysphagia is a common, serious complication in acute stroke patients, often requiring indwelling gastric tubes. Prolonged tube use increases risks of aspiration pneumonia and other adverse events. Current assessment methods often lack the sensitivity needed to guide safe extubati
Open articleNeurology
Effects of Single-Bout Endurance Exercise Intensity on Peripheral Neurotrophic Factors in Patients With Ischemic Stroke During the Subacute Phase of Rehabilitat
BACKGROUND Strong evidence suggests that a single session of aerobic exercise can alter serum neurotrophin concentrations and induce neural adaptations. This study aimed to analyze the effects of exercise intensity during a single exercise session on serum neurotrophin concentrat
Open articleNeurology
Successful pre-operative endovascular intraventricular meningioma embolization: a systematic review and pediatric case analysis. | ClinicLens
Intraventricular meningiomas are rare tumors accounting for a small fraction of intracranial meningiomas and are often associated with significant surgical challenges due to their deep location and rich vascular supply. Pre-operative endovascular embolization has been proposed as
Open articleNeurology
Clinical outcomes following cyberknife radiosurgery for cerebral arteriovenous malformations: A systematic review and meta-analysis. | ClinicLens
Despite the well-established efficacy of stereotactic radiosurgery in achieving obliteration of cerebral arteriovenous malformations (AVMs), a subset of patients, particularly those with large, deep-located AVMs, fail to achieve substantial obliteration. The CyberKnife machine of
Open articleNeurology
Phase 2b Trial of a NaV1.8 Inhibitor for Acute Pain | ClinicLens
New England Journal of Medicine, Volume 395, Issue 5, Page 454-464, July 30, 2026.
Open articleNeurology
Cross-Correction in HSC Gene Therapy for Metachromatic Leukodystrophy | ClinicLens
New England Journal of Medicine, Volume 395, Issue 5, Page 508-511, July 30, 2026.
Open articleNeurology
[Comment] Dementia prevention in Latin America and the Global South | ClinicLens
Dementia prevention is becoming a testable public health strategy. The 2024 Lancet Commission on dementia prevention, intervention, and care estimated that about 45% of dementia cases might be prevented or delayed by addressing 14 modifiable risk factors.1 Because the distributio
Open articleNeurology
[Articles] Multidomain lifestyle intervention for the prevention of cognitive decline in at-risk older adults in Latin America (LatAm-FINGERS): a single-blind,
A culturally adapted multidomain lifestyle intervention was feasible across Latin America and resulted in greater cognitive improvements than a flexible health-advice intervention in older adults at risk of cognitive decline. These findings extend the evidence base for multidomai
Open articleNeurology
Effect of High-Power Laser Therapy on Myoelectrical Activities of Suboccipital Muscles and Quality of Life in Patients with Cervicogenic Headache. | ClinicLens
Cervicogenic headache (CGH) is a secondary disorder caused by cervical musculoskeletal dysfunction in the cervical vertebrae, with involvement of the upper three cervical segments. The pain initiates in the neck and is often intensified by head or neck movements. This condition i
Open articleNeurology
Immunomodulation for stroke-associated pneumonia: a systematic review of mechanistic insight and emerging therapeutic strategies in animal models. | ClinicLens
Stroke-associated pneumonia (SAP) is a major infectious complication that increases mortality after stroke. Stroke-induced immunosuppression has been proposed as a key driver of SAP, supporting the rationale for immunomodulation. This review systematically outlines the immunopath
Open articleNeurology
A systematic review on the dual roles of microRNAs in ischemic stroke: mechanisms and effects. | ClinicLens
MicroRNAs (miRNAs) regulate key pathways in ischemic stroke with both protective and detrimental effects. Understanding these dual roles is important to developing novel therapeutic strategies for cerebral ischemia. This systematic review highlights key miRNAs under investigation
Open articleNeurology
Nonlinear dose-response effects of exercise interventions on post-stroke depression: a systematic review and meta-analysis. | ClinicLens
To systematically evaluate the effects of exercise interventions on post-stroke depression (PSD) and to clarify the dose-response relationship between physical activity dosage and depressive symptoms in individuals with PSD. A structured and comprehensive search was conducted in
Open articleNeurology
Predictive Performance of Artificial Intelligence Models for Stroke Risk Stratification: A Systematic Review and Meta-Analysis. | ClinicLens
BackgroundStroke remains a leading cause of mortality, long-term disability, and healthcare expenditure worldwide, placing substantial strain on healthcare systems, particularly in low- and middle-income countries. Effective risk stratification can facilitate targeted prevention
Open articleNeurology
Intravenous Thrombolysis Combined With Endovascular Treatment Versus Endovascular Treatment Alone in Acute Ischemic Stroke due to Tandem Lesions: A Systematic R
For patients suffering from acute ischemic stroke (AIS) brought on by tandem lesions (TL), to compare the safety and efficacy of intravenous thrombolysis (IVT) in conjunction with endovascular therapy (EVT) to EVT alone. Relevant studies published up until October 20, 2024, were
Open articleNeurology
Primary care-based interventions for post-stroke follow-up for long-term care: a systematic review. | ClinicLens
Life after stroke is managed by primary care to prevent recurrent stroke and ensure that stroke survivors live well within the community. Unfortunately, stroke survivors do not always receive timely follow-up from clinical services, which leads to unaddressed and hidden unmet nee
Open articleNeurology
Can executive functions be improved by playing board games across the lifespan? A systematic review and meta-analysis. | ClinicLens
Board games are usually played with other people across the lifespan. They seem to improve executive functions, which are psychological processes key to our daily lives. Therefore, this systematic review aimed to show whether board games could improve executive functions at diffe
Open articleNeurology
Transspinal stimulation preceding step training reorganizes spinal locomotor circuits in human spinal cord injury: a randomized sham-controlled clinical trial.
Activity-based rehabilitation, such as locomotor training, is commonly used to induce positive systemic physiological adaptations and restore locomotion in individuals with chronic spinal cord injury (SCI). Restoration of locomotion with activity-based rehabilitation alone is not
Open articleNeurology
Telemetric sensors for intracranial pressure monitoring in children with CSF shunts: a systematic review and narrative synthesis. | ClinicLens
Telemetric sensors are optionally inserted for intracranial pressure monitoring in paediatric hydrocephalus management. Children with shunted hydrocephalus may undergo multiple surgeries to investigate shunt function throughout their childhood. Understanding whether telemetric se
Open articleNeurology
Cervical Erector Spinae Plane Block vs. Epidural Steroid Injection for Cervical Radicular Pain: A Clinical Trial. | ClinicLens
Cervical radicular pain is a common chronic pain syndrome, typically managed with conservative treatments. In patients unresponsive to conservative management, minimally invasive interventions, such as an interlaminar cervical epidural steroid injection (ICESI), are employed. The
Open articleNeurology
Outcomes of rehabilitation following device-aided therapy start in parkinson's disease: a randomized controlled trial. | ClinicLens
To determine whether adding tailored primary care rehabilitation to Device-Aided Therapy in Parkinson's disease improves outcomes more than Device-Aided Therapy alone. Open randomized controlled intervention trial. Parkinson's patients initiating Device-Aided Therapy. P
Open articleNeurology
Systematic review of gut microbiota structural characteristics in patients with ischemic stroke. | ClinicLens
Emerging evidence implicates the gut microbiota (GM) in the pathogenesis of ischemic stroke (IS). However, systematic evaluations synthesizing evidence on microbial shifts, functional alterations, and clinical correlations are lacking. This study aimed to comprehensively analyze
Open articleNeurology
Endoscopic versus catheter-based minimally invasive evacuation of spontaneous supratentorial intracerebral hemorrhage: a systematic review and meta-analysis. |
Minimally invasive surgery (MIS) for spontaneous supratentorial intracerebral hemorrhage (sICH) includes endoscopic evacuation and catheter-based evacuation (aspiration or drainage Β± thrombolysis), but comparative performance remains uncertain. We performed a systematic review an
Open articleNeurology
Reinterpreting the Frequency Dependence of Cortical Auditory-Evoked Response Amplitudes in Light of Current Understanding of Cortical Tonotopic Organization. |
Tonotopy is a fundamental feature of auditory cortical organization, yet its influence on cortical auditory-evoked responses (AERs) remains unclear. Consequently, key properties of cortical AERs-such as their marked amplitude reduction with increasing stimulus frequency-still lac
Open articleNeurology
Culture Shapes the Neural Functional Alteration and Its Development in Children With Dyslexia: A Cross-Linguistic Meta-Analysis. | ClinicLens
How culture shapes brain functional alteration and its development remains poorly understood in dyslexia (DD). Hereby, we conducted a meta-analysis comparing brain activation in children across Chinese (logographic), English (deep alphabetic), and German (shallow alphabetic) writ
Open articleNeurology
Prevalence of dizziness in patients with temporomandibular disorders: a systematic review and meta-analysis. | ClinicLens
Temporomandibular disorders (TMDs) are characterised by pain and dysfunction in the temporomandibular joints and surrounding muscles. Dizziness is a frequent symptom reported by TMD patients, but the prevalence of dizziness in this population remains unclear. A systematic review
Open articleNeurology
Personality change after traumatic brain injury: a systematic review and meta-analysis. | ClinicLens
Personality change is a debilitating consequence of traumatic brain injury (TBI), yet its prevalence, characteristics, and treatment remain poorly understood. We completed a pre-registered (CRD42023440990) systematic review and meta-analysis searching four databases (MEDLINE, Psy
Open articleNeurology
Cardiovascular-kidney-metabolic syndrome stage modifies the efficacy of intensive blood pressure control on cognitive outcomes: A post hoc analysis of SPRINT MI
Whether cardiovascular-kidney-metabolic (CKM) syndrome stage modifies cognitive benefits of intensive blood pressure (BP) control remains unclear. This post hoc analysis of βSystolic Blood Pressure Intervention Trial - Memory and Cognition in Decreased Hypertension (SPRINT MIND)
Open articleNeurology
Development and Upgrade of a Robot That Enables Three-Dimensional Trunk Motion and Lower Limb Exercise for Stroke Patients: A Pilot Clinical Investigation Inclu
Stroke impairs functional independence including gait ability. While robot-aided rehabilitation techniques have been developed, there is a need for a robotic system that promotes three-dimensional (3D) movement of the trunk and gait ability while providing automatic function eval
Open articleNeurology
Effects of custom-made 3D-printed insoles on foot and body alignment in stroke survivors: an exploratory pilot randomized controlled trial. | ClinicLens
Stroke survivors frequently exhibit foot deformities and postural asymmetry, contributing to gait instability and increased fall risk. This exploratory pilot randomized controlled trial examined the effects of custom-made 3D-printed insoles on foot alignment and postural symmetry
Open articleNeurology
Phase III Open-Label, Randomized Clinical Trial of Epidermal Growth Factor and Growth Hormone Releasing Hexapeptide in Acute Ischemic Stroke. | ClinicLens
Stroke remains a critical condition. Combined therapy of Epidermal Growth Factor (EGF) and Growth Hormone Releasing Peptide-6 (GHRP6) has shown potential benefits in stroke patients. The present COURAGE-2 study hypothesized that intravenous EGF (75Β΅g) +GHRP6 (5mg) in acute ischem
Open articleNeurology
General Anesthesia Versus Non-GA in Endovascular Therapy for Acute Ischemic Stroke: A Systematic Review and Bayesian Meta-Analysis of RCTs. | ClinicLens
Endovascular thrombectomy (EVT) improves outcome in acute ischemic stroke (AIS) due to large vessel occlusion, yet the optimal anesthetic strategy remains controversial. Previous meta-analyses using frequentist methods reported no significant differences between general anesthesi
Open articleNeurology
Comparative efficacy and safety of photobiomodulation, transcranial direct current stimulation, and repetitive transcranial magnetic stimulation in Alzheimer&#x
Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which current pharmacological therapies provide only modest and transient benefits, underscoring the need for effective non-pharmacological interventions. Non-invasive brain stimulation (NIBS), includin
Open articleNeurology
Efficacy and Safety of Mesenchymal Stem Cell Therapy for Alzheimer's Disease: A Systematic Review and Meta-Analysis. | ClinicLens
Alzheimer's disease (AD) is the leading cause of dementia, and effective disease-modifying therapies remain limited. Mesenchymal stem cells (MSCs) have shown therapeutic potential because of their neuroprotective and immunomodulatory properties, but clinical evidence remains
Open articleNeurology
Changes in cortical plasticity induced by paired associative stimulation in people with mild cognitive impairment and Alzheimer's disease: a systematic rev
Paired associative stimulation (PAS) is a non-invasive neuromodulation paradigm capable of inducing long-term potentiation (LTP)- or long-term depression (LTD)-like plasticity. It has been used to probe neuroplasticity and corticospinal excitability alterations in Alzheimer'
Open articleNeurology
Evaluating the User Experience and Therapeutic Efficacy of Humanoid Socially Assistive Robots in Alzheimer's Disease and Related Dementias (ADRD) Care. | C
Addressing neuropsychiatric symptoms in Alzheimer's Disease and Related Dementias (ADRD) requires scalable, non-pharmacological interventions. This study evaluated the user experience and clinical efficacy of a humanoid Socially Assistive Robot (SAR) in an ADRD care setting.
Open articleNeurology
Comparison of ABBV-552 Safety and Pharmacokinetics in Healthy Asian and Western Adults. | ClinicLens
ABBV-552, a positive modulator of synaptic vesicle glycoprotein 2A (SV2A), was under investigation as a treatment for cognitive impairment related to Alzheimer's disease. This Phase 1, multicenter, open-label, parallel cohort study (NCT05686980) was conducted to examine the
Open articleNeurology
Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort. | Clini
Understanding the genetic foundations of dementia is critical to unraveling its complex molecular basis. Given that a clinical diagnosis of Alzheimer's disease (AD) dementia often results from interplay between multiple underlying neuropathologic co-morbidities, previous gen
Open articleNeurology
Comparative efficacy and safety of pathway-targeted pharmacotherapies for Alzheimer's disease: A systematic review and network meta-analysis of phase III t
To compare the efficacy and safety of pharmacotherapies targeting different pathological pathways in Alzheimer's disease (AD). We systematically searched PubMed, Embase, the Cochrane Library, Web of Science, ClinicalTrials.gov, and AlzForum for randomized controlled trials (
Open articleNeurology
A reappraisal of APOE genetic effects on Alzheimer's disease risk in the Japanese population: a meta-analysis. | ClinicLens
Our meta-analysis demonstrates that the risk effect of APOE-e4*4 relative to APOE-e3*3 for Alzheimer's disease in the Japanese population is approximately 12-15-fold, comparable to that reported in Caucasian populations, rather than greater than 20-fold as previously reporte
Open articleNeurology
Clinico-biological trajectories stratified by combined tau biomarkers in preclinical Alzheimer's disease. | ClinicLens
Tau pathology biomarkers provide prognostic indicators of neurodegeneration and cognitive decline in Alzheimer's disease (AD), making them crucial to early patient stratification for disease-modifying interventions. Plasma p-tau217 indexes early tau pathophysiology, whereas
Open articleNeurology
Use of Sedative-Hypnotic Drugs and the Risk of Developing Alzheimer's Disease: A Systematic Review, Meta-Analysis and Meta-Regression. | ClinicLens
Sedative-hypnotics, including benzodiazepines (BZDs) and non-benzodiazepine hypnotics (Z-drugs), are widely prescribed for insomnia and anxiety, particularly in older adults. Their long-term cognitive safety and potential association with Alzheimer's disease (AD) remain unce
Open articleNeurology
Gabapentinoid Use and Risk of Alzheimer's Disease-Related Dementias: A Systematic Review and Meta-analysis of Observational Studies. | ClinicLens
Gabapentinoids, particularly gabapentin and pregabalin, are widely prescribed for neuropathic pain and other chronic conditions, including in populations at risk for cognitive decline. Their long-term cognitive safety and potential association with Alzheimer's disease and re
Open articleNeurology
Cannabinoids Treatment for Agitation in Alzheimer's Disease: A Systematic Review and Meta-Analysis With Bayesian and Sequential Trial Analyses. | ClinicLen
Agitation and related neuropsychiatric symptoms are common in Alzheimer's disease (AD) and contribute to caregiver burden, functional decline, and institutionalization. Cannabinoid-based therapies have been investigated as potential symptomatic interventions, but evidence re
Open articleNeurology
NegotiAge-An AI-Based Caregiver Negotiation Training: Results From the Multiphase Optimization Strategy (MOST) Trial. | ClinicLens
Family caregivers experience conflicts in caring for people with Alzheimer's dementia (PWD; e.g., siblings disagreeing, advocating with providers, PWD refusing assistance). Subsequently, family caregivers experience frustration, burden, and stress. Furthermore, these caregiv
Open articleNeurology
The impact of cognitive behavioral therapy for insomnia on cognitive performance and amyloid beta in older adults: A randomized controlled trial. | ClinicLens
Insomnia is associated with increased risk for Alzheimer's disease (AD). It is unknown how cognitive behavioral therapy for insomnia (CBT-I) impacts two hallmarks of AD progression, cognitive performance and beta-amyloid (AΞ²) burden. Cognitively normal older adults with symp
Open articleNeurology
Donanemab treatment effect by baseline tau burden and disease severity: Observations from the TRAILBLAZER-ALZ 2 trial. | ClinicLens
Clinical trials indicate that disease-modifying therapies can slow clinical decline in Alzheimer's disease (AD), with earlier initiation associated with greater slowing. In the TRAILBLAZER-ALZ 2 trial, the treatment effect of donanemab on the Clinical Dementia Rating Scale S
Open articleNeurology
Semaglutide showed limited improvements in patients with Alzheimer's disease: Revisiting the evoke and evoke + clinical trials. | ClinicLens
BackgroundSemaglutide is a glucagon-like peptide-1 analog that is on the market to treat type 2 diabetes and weight loss (Ozempic, Wegovy). Two phase 3 clinical trials have been conducted, Evoke and Evoke+, testing the drug in patients with Alzheimer's disease. The trial man
Open articleNeurology
Depression as a prognostic factor for conversion from mild cognitive impairment to all-cause dementia and Alzheimer's disease: a systematic review and meta
Mild cognitive impairment (MCI) is a transitional stage between normal aging and dementia, with annual conversion rates to Alzheimer's disease (AD) or all-cause dementia estimated at 10%-15%. The role of depression as a prognostic factor for dementia progression remains uncl
Open articleNeurology
A systematic review and meta-analysis of metalloproteinases in patients with Alzheimer's disease and mild cognitive impairment. | ClinicLens
BackgroundVarious studies have reported altered expression of metalloproteinases in Alzheimer's disease (AD); however, expression profiles of each metalloproteinase during cognitive decline have not yet been fully characterized.ObjectiveThe purpose of this systematic review
Open articleNeurology
Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementias. | ClinicLens
To better characterize the genetic architecture underlying Alzheimer's disease (AD) and related dementias (ADRD), we performed a meta-analysis of European-ancestry genome-wide association studies in 128,681 cases or proxy cases of ADRD and 849,833 (proxy) controls. We identi
Open articleNeurology
Gain-of-function Modulation of TREM2 and its Impact on Amyloid-Ξ² and Tau Pathologies in Alzheimer's Disease: A Systematic Review and Meta-analysis of Anima
Alzheimer's disease (AD) is characterized by amyloid-Ξ² (AΞ²) deposition, hyperphosphorylated Tau accumulation, and chronic neuroinflammation, with microglial function playing a crucial role in modulating these pathological cascades. The microglial receptor TREM2 has emerged a
Open articleNeurology
Cerebellar rTMS ameliorates cognitive impairment in Alzheimer's disease: A randomized trial. | ClinicLens
Developing effective neuromodulatory therapies for Alzheimer's disease (AD) is a critical unmet need. While repetitive transcranial magnetic stimulation (rTMS) shows promise, its optimal targets and mechanisms remain incompletely understood. The cerebellum, a key modulator o
Open articleNeurology
Biomarkers of angiogenesis in Alzheimer's disease: Systematic review and meta-analysis. | ClinicLens
BackgroundCerebrovascular dysfunction can contribute to the pathophysiology of Alzheimer's disease (AD) and trigger angiogenesis. To date, no prior systematic review and meta-analysis (SRMA) study has attempted to qualitatively and quantitatively review existing literature e
Open articleNeurology
Comparison of [18F]flortaucipir and [18F]MK6240 for the detection of tau pathology in Alzheimer's disease (HEAD): a multicentre, prospective, cross-section
Tau PET imaging has emerged as a critical biomarker for Alzheimer's disease, informing diagnosis, staging, and therapeutic selection. We investigated whether PET tracer selection alters tau detection. We conducted a prospective, multicentre, non-randomised, within-participan
Open articleNeurology
Synaptic biomarkers in Alzheimer's disease dementia and mild cognitive impairment: A systematic review and meta-analysis. | ClinicLens
Alzheimer's disease (AD) is characterized by synaptopathy, a neuropathological feature that can contribute to underlying cognitive decline. Here, we evaluate potential cerebrospinal fluid (CSF) and blood-based synaptic biomarkers in AD dementia and its earliest clinical stag
Open articleNeurology
Efficacy and safety of DMB-I (latrepirdine) therapy in mild to moderate dementia in Alzheimer's disease: results of a multicenter, double-blind, randomized
Alzheimerβs disease (AD) is one of leading dementia causes, affecting over 50 million people worldwide. A multicenter, double-blind, randomized, placebo-controlled clinical trial in three parallel groups was conducted to evaluate efficacy and safety of Latrepirdine polymorph DMB-
Open articleNeurology
Treatment of Clinically Diagnosed Alzheimer's Disease by External Counterpulsation A Randomized Clinical Trial. | ClinicLens
ObjectiveTo assess external counterpulsation (ECP) effects on cognitive and functional decline in early AD.MethodsThis 12-month, multicenter, blinded, randomized, sham-controlled trial enrolled 190 patients with early AD (MCI due to AD or mild AD per NIA-AA clinical criteria). Pa
Open articleNeurology
Clinical Meaningfulness of Donanemab in Early Symptomatic Alzheimer Disease: Data From the Randomized Phase 3 TRAILBLAZER-ALZ 2 Trial. | ClinicLens
Understanding the meaningfulness of clinical trial outcomes is essential for people living with Alzheimer disease (AD) and their clinicians to make evidence-based shared treatment decisions in real-world clinical care. Donanemab, a monoclonal antibody targeting the insoluble form
Open articleNeurology
Effectiveness of Sensorimotor and Balance Training Compared to Conventional Physiotherapy on Balance and Quality of Life in Chemotherapy-Induced Peripheral Neur
Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side effect that leads to sensory deficits, impaired balance, and a reduced quality of life (QoL). This study evaluates the effectiveness of sensorimotor and balance training compared with conventional physiother
Open articleNeurology
Neuroprotection and prevention of oxaliplatin-induced neuropathy with Huangqi Guizhi Wuwu Decoction: a 12-center randomized, double-blind trial with mechanistic
Oxaliplatin-induced peripheral neuropathy (OIPN) affects up to 80% of patients receiving oxaliplatin-based chemotherapy, and effective preventive strategies remain limited. Huangqi Guizhi Wuwu Decoction (HQGZWWD), a traditional Chinese herbal formula included in China's Nati
Open articleNeurology
Arbovirus-Associated Guillain-BarrΓ© Syndrome: A Systematic Review and Meta-Analysis of Clinical Characteristics, Subtypes, and Vaccine Associations. | ClinicLen
Arboviral infections are increasingly recognized as triggers of Guillain-BarrΓ© syndrome (GBS), yet the clinical spectrum, subtype distribution, and strength of association across different arboviruses remain incompletely characterized. This systematic review and meta-analysis eva
Open articleNeurology
Effect of Admission Diabetes History on Safety and Efficacy of Early Tirofiban Infusion after Intravenous Thrombolysis in Ischaemic Stroke: a post-hoc analysis
This study aimed to investigate how diabetes mellitus (DM) influences the efficacy of early tirofiban administration after intravenous thrombolysis in patients with acute ischaemic noncardioembolic stroke. This was a post-hoc analysis of the ASSET-IT (Advancing Stroke Safety and
Open articleNeurology
Photobiomodulation with or without ILIB in diabetic peripheral neuropathy: a randomized pilot trial. | ClinicLens
Diabetic peripheral neuropathy is a disabling chronic complication of diabetes mellitus, associated with neuropathic pain, sensory dysfunction, and reduced quality of life. Because pharmacological treatments often provide only partial relief, photobiomodulation therapy (PBMT) has
Open articleNeurology
Does lifestyle intervention lower clinically significant cognitive impairment risk? | ClinicLens
Multidomain lifestyle interventions have been demonstrated to benefit cognitive function but it is unknown whether they reduce risk for clinically significant cognitive impairment sCI (mild cognitive impairment or dementia). The Action for Health in Diabetes administered repeated
Open articleNeurology
The effects of high-intensity interval training on glucose metabolism, inflammatory responses, and functional recovery in patients with diabetic peripheral neur
The aim of this study is to investigate, through a randomised controlled trial, the effects of high-intensity interval training (HIIT) on glucose metabolism, inflammatory responses and neurological recovery in patients with diabetic peripheral neuropathy (DPN), and to compare the
Open articleNeurology
Placebo-controlled three-armed pilot trial of Escitalopram or Nortriptyline for depressive symptoms in Parkinson's disease (ADepT-PD). | ClinicLens
Pilot randomised-controlled trial of nortriptyline and escitalopram compared to placebo for depressive symptoms in people with Parkinson's disease (PD). Participants with PD and depressive symptoms received either nortriptyline, escitalopram or placebo with assessments at ba
Open articleNeurology
The burden of seizure emergencies in spain: a systematic literature review. | ClinicLens
Seizure emergencies pose significant clinical and healthcare challenges in Spain, impacting morbidity, mortality, and resource utilization. Comprehensive data on epidemiology, clinical outcomes, and economic impact remain limited. A systematic review was conducted following the C
Open articleNeurology
Efficacy and safety of immersive, sEMG-triggered virtual reality game training for post-stroke dysphagia: a randomized, single-blind, controlled trial. | Clinic
Post-stroke dysphagia (PSD) is a common and serious complication. Traditional rehabilitation for PSD is often hampered by low patient adherence due to its unengaging nature. This study aimed to evaluate the efficacy and safety of an immersive, surface electromyography (sEMG)-trig
Open articleNeurology
'Better Conversations with Primary Progressive Aphasia and other rare dementias (BCPPA plus)' telehealth communication partner training programme: pro
Language and communication difficulties are common across a range of dementias including primary progressive aphasia (PPA). Better Conversations with PPA (BCPPA) is a co-designed communication partner training intervention that aims to improve the experience of conversations for
Open articleNeurology
Methodological determinants and prevalence of elevated intracranial pressure in isolated single-suture craniosynostosis: a systematic review and meta-analysis.
Elevated intracranial pressure (ICP) in isolated single-suture craniosynostosis (SSC) may contribute to neurodevelopmental impairment, yet reported prevalence varies widely. This systematic review and meta-analysis estimate the pooled prevalence of elevated ICP in isolated SSC an
Open articleNeurology
The Use of a Handheld Non-Invasive Vagal Nerve Stimulation (nVNS) Device for the Treatment of Long COVID: A Pilot Randomized Controlled Trial. | ClinicLens
ObjectivesLong-term symptoms following infection with acute respiratory syndrome coronavirus-2 (SARS-CoV-2), termed post-acute sequelae of SARS-CoV-2 infection (PASC) or Long COVID (LC), persist beyond 90 days and may impact at least 10% of patients with acute infection. The exac
Open articleNeurology
Dental Caries Experience in Older Adults With Parkinson's Disease: A Systematic Review and Meta-Analysis. | ClinicLens
This systematic review and meta-analysis assessed whether individuals with Parkinson's disease (PD) have higher dental caries rates than those without PD. Seven electronic databases and gray literature sources were systematically searched for observational studies comparing
Open articleNeurology
Risk of False-Positives With Alzheimer Disease Blood Test | ClinicLens
This Medical News article discusses a recent study in JAMA Neurology about the real-world use of the first approved plasma test for biomarkers of Alzheimer disease pathology.
Open articleNeurology
Motivational Coaching Cues Can Modulate Prefrontal Cortex Activity and Perceptual Responses of Elite Football Players During High-Intensity Interval Training: A
Football coaches commonly provide verbal encouragement and exercise end-point feedback to sustain players' effort by enhancing motivation during fitness training such as high-intensity interval training (HIIT). However, the influence of such cues on the prefrontal cortex (PF
Open articleNeurology
Shockwave Therapy or Acupoint Stimulation Combined With Physiotherapy for Spasticity and Motor Function in Post-Stroke Recovery: A Randomized Controlled Trial.
Stroke frequently causes spasticity and motor impairment, reducing independence. Non-invasive treatments like radial extracorporeal shockwave therapy (ESWT) and acupoint-based transcutaneous electrical nerve stimulation (Acu-TENS) show potential, but direct comparisons with physi
Open articleNeurology
IV Thrombolysis in the Extended Time Window for Acute Ischemic Stroke: An Updated Systematic Review and Meta-Analysis. | ClinicLens
IV thrombolysis (IVT) is the standard treatment for acute ischemic stroke (AIS) within 4.5 hours of symptom onset, yet many patients present beyond this window. Recent randomized-controlled clinical trials (RCTs) and updated guidelines suggest potential benefit of IVT in selected
Open articleNeurology
Clinical and preclinical evidence of meningeal immunity and glymphatic pathways in stroke: a systematic review. | ClinicLens
Glymphatic transport, meningeal lymphatic drainage, and meningeal immunity have been implicated in metabolic waste clearance, cerebral edema formation, and the regulation of neuroinflammation after stroke. However, the available evidence remains fragmented and has not been system
Open articleNeurology
Motor imagery-based brain-computer interface training for post-stroke upper limb dysfunction: systematic review and meta-analysis. | ClinicLens
Motor imagery-based brain-computer Interface (MI-BCI) utilises electroencephalographic signals from imagined limb movements for control commands, enabling real-time interaction with external devices. Clinical trials suggest its potential for upper limb recovery post-stroke. This
Open articleNeurology
[Effect of acupuncture of "twelve hand and foot acupoints" combined with neural mobilization on limb motor function in patients with cerebral infarcti
To observe the effect of acupuncture of "twelve hand and foot acupoints" (in fact "12 acupoints on the hands and feet") combined with neural mobilization intervention (a manual treatment method that directly applies force to some related nerve tissue through t
Open articleNeurology
Ranking psychological interventions for post-stroke depression: A systematic review and network meta-analysis. | ClinicLens
Post-stroke depression (PSD) is the most common neuropsychological complication in stroke survivors. While psychological interventions are promising non-pharmacological treatments, the most effective intervention type, as well as their mid- to long-term efficacy and effectiveness
Open articleNeurology
Exploring Between-Study Heterogeneity in Extended-Window IV Thrombolysis for Acute Ischemic Stroke: A Meta-Analysis of 18 Randomized Controlled Trials. | Clinic
IV thrombolysis (IVT) is the standard-of-care evidence-based treatment of eligible patients with acute ischemic stroke (AIS) within 4.5 hours of symptom onset. Emerging evidence supports its use beyond this time window, leading to expanded recommendations for selected patients pr
Open articleNeurology
Adaptive pathways for multimodal community-based detection of cognitive impairment: the CogScreen I study. | ClinicLens
Early detection of cognitive impairment is essential for dementia prevention and timely care. However, implementation in primary care and community settings remains limited. Building dementia-prepared health systems requires scalable and adaptive pathways that integrate subjectiv
Open articleNeurology
Predictors of Multiple Sclerosis After Clinically Isolated Syndrome: A Systematic Review and Meta-Analysis. | ClinicLens
Most people with multiple sclerosis (MS) present with a clinically isolated syndrome (CIS); however, not all individuals with CIS are subsequently diagnosed with MS. A systematic literature review was conducted until December 2025. Observational studies of adults with CIS that we
Open articleNeurology
Testing neuromuscular feedback therapy in patients with chronic spinal cord injury with residual motor function in the lower extremities compared to 'conve
Multicentre randomised controlled trial. Eight spinal cord injury (SCI) centres and 15 rehabilitation centres in Germany. To demonstrate the superiority of neuromuscular feedback therapy using an exoskeleton compared to conventional therapy in terms of improving walking ability i
Open articleNeurology
Central nervous system histopathological findings in classic infantile Pompe disease: a systematic review with clinical relevance. | ClinicLens
Classic infantile Pompe disease is the most severe phenotype within the clinical spectrum of Pompe disease and is characterized by central nervous system (CNS) involvement. A systematic review on histopathological findings in classic infantile Pompe disease was conducted using Em
Open articleNeurology
Effect of mirror therapy combined with transcranial direct current stimulation on upper limb motor function in stroke patients: A meta-analysis. | ClinicLens
Upper limb motor impairment is a major contributor to long-term disability after stroke. Mirror therapy (MT) promotes motor relearning through visuomotor feedback, whereas transcranial direct current stimulation (tDCS) may facilitate neuroplasticity by modulating cortical excitab
Open articleNeurology
A 36-Year-Old Woman with Left-Sided Weakness and Difficulty Speaking. | ClinicLens
AbstractMorning Report is a time-honored tradition where physicians-in-training present cases to their colleagues and clinical experts to collaboratively examine an interesting patient presentation. The Morning Report section seeks to carry on this tradition by presenting a patie
Open articleNeurology
Cognitive Motor Dissociation in Disorders of Consciousness: An Individual Participant Data Meta-Analysis. | ClinicLens
In patients with disorders of consciousness (DoC), behavioral assessment often underestimates awareness when motor output is absent or unreliable. Cognitive motor dissociation (CMD) refers to patients who appear unresponsive but demonstrate volitional brain responses during neuro
Open articleNeurology
Antithrombotic treatment for migraine in patients with patent foramen ovale: multicentre, randomised, active controlled, open label trial. | ClinicLens
To evaluate the efficacy and safety of antithrombotic treatment for migraine prevention in participants with patent foramen ovale (PFO). Investigator initiated, multicentre, prospective, randomised, active controlled, open label clinical trial with blinded outcome assessment and
Open articleNeurology
Testing neuromuscular feedback therapy in patients with chronic spinal cord injury with residual motor function in the lower extremities compared to 'conve
Study design Multicentre randomised controlled trial. Setting Eight spinal cord injury (SCI) centres and 15 rehabilitation centres in Germany. Objectives To demonstrate the superiority of neuromuscular feedback therapy using an exoskeleton compared to conventional therapy in term
Open articleNeurology
Artificial intelligence tools for the assessment and management of dysphagia: a scoping review | ClinicLens
Objectives To explore the existing artificial intelligence (AI) tools used in the assessment and management of dysphagia. Design Scoping review. Data sources MEDLINE (Ovid), Scopus, CINAHL (EBSCOhost), Cochrane Library, Joanna Briggs Institute (JBI) Evidence Synthesis, ProQuest a
Open articleNeurology
Preventing the next stroke: nurse-led decision and adherence coaching to empower people with stroke (StrokeCompass) versus usual care - study protocol for a ste
Introduction Recurrent stroke prevention is important for people who have suffered a stroke or transient ischaemic attack (TIA), as they are at increased risk of having another stroke. Nevertheless, treatment adherence is often low. Therefore, the StrokeCompass project was initia
Open articleNeurology
Safety, Tolerability, Pharmacokinetics, Food Effect of Ribitol, and Its Effect on QTcF in Healthy Adults: First-in-Human, Randomized, Double-Blind (Sponsor Unbl
Limb-girdle muscle dystrophy Type R9 (LGMDR9), also known as LGMD Type 2I, is a rare genetic disease caused by partial loss of function of fukutin-related protein (FKRP) enzyme which glycosylates alpha-dystroglycan, thereby stabilizing myocytes during contraction. Hypoglycosylati
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