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To integrate evidence from randomized controlled trials (RCTs) comparing subcutaneous (SC) and oral methotrexate (MTX) for rheumatoid arthritis (RA) to provide optimal clinical treatment strategies. This meta-analysis conducted comprehensive search of PubMed, Web of Science, Emba
Open articleRheumatology
New England Journal of Medicine, Volume 395, Issue 5, Page 492-492, July 30, 2026.
Open articleRheumatology
New England Journal of Medicine, Volume 395, Issue 5, Page 493-501, July 30, 2026.
Open articleRheumatology
New England Journal of Medicine, Ahead of Print.
Open articleRheumatology
New England Journal of Medicine, Ahead of Print.
Open articleRheumatology
Fibromyalgia (FM) is a chronic condition characterized by widespread pain and a range of somatic and psychological symptoms that impose a substantial burden on patients. While pregabalin is an approved and effective monotherapy for many individuals with FM, the efficacy of this m
Open articleRheumatology
This systematic literature review (SLR) aims to update the evidence regarding therapeutic strategies in difficult-to-treat rheumatoid arthritis (D2T RA), building on the previous SLR informing the European Alliance of Associations for Rheumatology (EULAR) points to consider for t
Open articleRheumatology
Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome is a rare autosomal recessive autoinflammatory disorder caused by mutations affecting proteasome function. Given the absence of standard therapy, we reviewed the therapeutic pot
Open articleRheumatology
Current guidelines recommend influenza and pneumococcal vaccination in the majority of patients with rheumatic diseases. This study aimed to summarize the coverage of influenza and pneumococcal vaccines among these patients. A literature search was conducted in PubMed, Embase, We
Open articleRheumatology
Rheumatoid Arthritis (RA), as a common autoimmune disease, not only causes damage to the joints themselves, but also increases the risk of developing other diseases. In recent years, the association between RA and malignant tumors has attracted increasing attention. Most studies
Open articleRheumatology
This phase II trial aimed to evaluate the efficacy and safety of SSGJ-613, a fully human anti-interleukin 1β monoclonal antibody, compared with compound betamethasone (CB) in Chinese patients with acute gouty arthritis. In this multicenter, double-blind, double-dummy, active-cont
Open articleRheumatology
This Phase Ib/II study aimed to evaluate the safety, tolerability, pharmacokinetics, and efficacy of Firsekibart in the treatment of gout flares. Phase Ib part utilized an open-label, single-dose, dose-escalation design. Patients were enrolled and received a single subcutaneous i
Open articleRheumatology
Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with metabolic dysfunction-associated steatotic liver disease (MASLD), which may contribute to cardiovascular (CV) risk. This study aimed to examine the association between hepatic steatosis, measured by a non-i
Open articleRheumatology
To systematically evaluate the clinical efficacy of heat therapy for hand osteoarthritis. Systematic review and meta-analysis of randomized controlled trials (RCTs). 9 RCTs (n = 627) from 13 identified studies included in meta-analysis. Databases were searched up to 19 December 2
Open articleRheumatology
To investigate the clinical efficacy of separated moxibustion in the treatment of rheumatoid arthritis (RA) and related negative emotions based on gut microbiota, so as to explore its potential mechanism of action. A total of 70 RA patients were randomly divided into a control gr
Open articleRheumatology
This study aims to compare intranasal dexmedetomidine with inhaled nitrous oxide for procedural pain relief and sedation during intra-articular injections in a pediatric rheumatology outpatient clinic. Patients from 1 to 18 years-of-age requiring 1-5 intra-articular injections we
Open articleRheumatology
Inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) are common autoimmune disorders that have a serious impact on the physical and mental health of patients. Some patients with AS also suffer from IBD, and some studies have shown that there is a link between the 2. H
Open articleRheumatology
Pulmonary involvement (PI) in ANCA-associated vasculitis (AAV), especially interstitial lung disease (ILD) and diffuse alveolar hemorrhage (DAH), predicts poor outcomes, but a synthesis distinguishing these phenotypes is lacking. We searched seven databases up to April 1, 2026, a
Open articleRheumatology
Objective To map the current evidence on components of fitness, physical activity and health-related quality of life, in addition to common fitness and health-related quality of life outcomes and assessment tools, explore existing evidence on the design and effects of muscle-stre
Open articleRheumatology
Fibromyalgia is a chronic pain syndrome characterized by widespread pain, fatigue, and sleep disturbance. Many patients remain symptomatic despite guideline-concordant pharmacologic therapy. Stellate ganglion block (SGB) modulates sympathetic activity and may provide an adjunctiv
Open article